Research updates on determinants of parental COVID- 19 vaccine hesitancy for juvenile

Vaccination is the most effective prevenative measure against infectious diseases. As guardians of minor children, parental attitudes have a decisive influence on children's vaccination. Therefore, it is very important to understand parental attitudes and preference towards the vaccination of minor children in COVID-19 for the successful implementation of vaccination. In this study, the current situation and associated factors of parental COVID-19 vaccine hesitancy for children. It was found that parental vaccine hesitation was mainly influenced by factors related to parents, children, vaccination and information process. Parents should be guided to obtain information through authoritative channels and treat vaccination correctly. At the same time, medical staff should play an important role in health education, submit correct immunisation information, reduce vaccine hesitancy, and promote herd immunity. © 2022 Chinese Academy of Sciences. All rights reserved.

Service design touch point failure model and effect analysis based on the triangular fuzzy number evaluation method

How to improve employees' satisfaction in the remote office mode while working together has become a challenge for enterprises to deal with the new office management mode. The concept of service design touch point is introduced into the remote office management system to improve employees' office experience and help enterprises complete the remote office service design. From the perspective of virtuous circle, the cost of failure analysis and preventive measures for service design touch point in the process of service design is lower than that of dealing with failure after service failure. Therefore, this paper made a risk assessment on the failure mode of service design touch point loss analysis method based on the triangular fuzzy number evaluation method. In the failure risk assessment, the fuzzy failure mode and effect analysis theory and the failure mode of service design touch point are analyzed first, and the expert scoring method is used to evaluate and determine the fuzzy level of severity, occurrence and detection of each failure mode;Then, aiming at the ability difference of different experts in evaluating different objects, the expert importance matrix, which is based on attribute difference, is determined;On this basis, the risk priority value of each failure mode is analyzed and determined by fuzzy calculation method. The risk evaluation ranking results of touch point failure modes are obtained according to the risk priority value. Finally, taking the failure analysis of Y company's remote collaborative office service as an example, the feasibility of the method is verified by the case of protection during COVID-19.

Effects of SARS‑CoV‑2 on testicular function

Objective: To describe the clinical characteristics of the male reproductive system of COVID‑19 patients and to explore the presence of SARS‑CoV‑2 in semen. Methods: Case series of 112 male patients with confirmed COVID‑19 who were admitted to Renmin Hospital of Wuhan University from January to March, 2020. Demographic data, symptoms and signs related to the male reproductive system, throat swabs and semen samples were collected and analyzed. SARS‑CoV‑2 RNA levels were measured in throat swab and semen samples. The organ distribution of ACE2 mRNA and protein in human tissue on HPA database were investigated. Results: The HPA dataset revealed relatively high levels of ACE2 protein and RNA expression in testis. A total of 3 severe COVID‑19 patients (2.7%) presented with orchidoptosis, while no patient experienced other symptoms or signs related to the male reproductive system. The analysis of SARS‑CoV‑2 RNA in semen included 17 patients with fertility needs. In the semen SARS‑CoV‑2 analysis, all 17 patients were negative for the N gene and ORF1ab gene. Conclusion: The online datasets indicated the potential impairment of the testicular function by SARS‑CoV‑2. However, this study suggestes that male patients have few reproductive symptoms and signs, and SARS‑CoV‑2 was not present in the semen of patients with confirmed COVID‑19. In view of the potential impairment, the long‑term follow‑up for male COVID‑19 patients with fertility needs is of great significance. © 2022, Editorial Board of Medical Journal of Wuhan University. All right reserved.

SWOT Analysis and Preliminary Study on Prevention and Control Management of Temporary Integrated Isolation Ward During COVID-19 Outbreak.

Background: The world faced crises of prevention and control and shortage of medical resources during the COVID-19 (Corona Virus Disease 2019) outbreak. The establishment of temporary integrated isolation wards in hospitals, which is universal and representative in China, is one of the most-effective strategies in solving these problems according to China's experiences. Aim: To conduct a preliminary study on the establishment of a temporary integrated isolation ward during the outbreak of COVID-19 and to evaluate related impact. Methods: SWOT analysis was used to analyze the advantages, disadvantages, opportunities, and risks in the establishment of the temporary integrated isolation ward, and corresponding corrective measures were made according to the analysis results. Findings: The ward has formulated more than 10 related work procedures and prevention and control measures. A total of 93 patients with 18 critically ill patients were admitted for treatment and isolation. They were all evaluated based on established procedures and protocols. Twenty-four supplementary nucleic acid tests were ordered and conducted. One new patient with COVID-19 was confirmed and was successfully transferred to the designated COVID-19 infectious control hospital. There were no missed diagnosis or misdiagnosis, no cross-infection of patients, no cluster outbreak, and no infection of medical workers during the entire process. Conclusion: SWOT analysis is helpful in guiding the establishment of a temporary integrated isolation ward and the formulation of prevention and control measures in Hebei General Hospital during the COVID-19 outbreak. It provides the guidance and reference of significance for the establishment of similar types of wards in the future.

The Impact Analysis of COVID-19 on China Various Industries Using Crawler Technology and Data Visualization Technology

In order to stop the spread of COVID-19, government has to lockdown of the city from all outside contact. Most of business activities force to stop. This will have an impact on the economic activities. In this paper, first we will use the crawler technology to fetch company's data from Cninfo website. Second, we will use the big data analysis and data visualization technology to analyze the impact of Covid-19 on China various industries. In comparing various industries' profit in the first quarter of 2019 and 2020, we find that except for agriculture, forestry, animal husbandry and fishery, national defense and military, banking, food and beverage industries, the profit value of other industries has declined, with transportation, chemical industry, mining and non-banking financial sector falling the most. On the whole, various industries have been hit by the epidemic. © 2020 IEEE.

[Novel coronavirus induces testicular injury: Analysis of causes and follow-up monitoring]

The outbreak of coronavirus disease 2019 (COVID-19) caused by 2019 novel coronavirus has become a global public health challenge. In addition to the typical respiratory symptoms, COVID-19 can induce damage to testicular spermatogenesis. This study focuses on the possible causes and follow-up monitoring of testicular injury induced by COVID-19.

The Impact of COVID-19 on Brachytherapy During the Pandemic: A Rutgers-Robert Wood Johnson Barnabas Health Multisite Experience.

PURPOSE: This study aimed to evaluate whether the coronavirus disease of 2019 (COVID-19) pandemic resulted in treatment delays in patients scheduled for or undergoing brachytherapy. METHODS AND MATERIALS: A retrospective cohort study was conducted across 4 affiliated sites after local institutional review board approval. The eligibility criteria were defined as all patients with cancer whose treatment plan included brachytherapy during the COVID-19 pandemic from February 24, 2020 to June 30, 2020. Treatment delays, cancellations, alterations of fractionation regimens, and treatment paradigm changes were evaluated. RESULTS: A total of 47 patients were eligible for the analysis. Median patient age at the time of treatment was 62 years (interquartile range, 56-70 years). Endometrial, cervical, and prostate cancers were the most common sites included in this analysis. Three patients (6.4%) with cervical cancer were diagnosed with COVID-19 during the course of their treatment. Interruptions of external beam radiation therapy (EBRT), cancellations of EBRT, cancellations of brachytherapy, and treatment delays due to COVID occurred in 5 (10.6%), 3 (6.4%), 8 (17%), and 9 (19%) patients, respectively. The mean and median number of days delayed for patients who experienced treatment interruptions were 16.3 days (standard deviation: 13.9 days) and 14 days (interquartile range, 5.75-23.75 days), respectively. For patients with cervical cancer, the mean and median overall treatment times defined as the time from the start of EBRT to the end of brachytherapy were 56 and 49 days, respectively. CONCLUSIONS: Despite the challenges the health care system faced during the pandemic, most patients with cancer were safely treated with minor treatment delays and interruptions. Long-term follow up is needed to assess the impact of COVID-19 and treatment interruptions on oncologic outcomes.

High risk factors associated with severity of COVID-19 patients

Objective To explore the high risk factors associated with severity of coronavirus disease-2019 (COVID-19) to provide a basis for precise diagnosis and treatment. Methods The clinical data of COVID-19 patients admitted to Fuyang Second People's Hospital in Anhui Province from Jan. 20, 2020 to Feb. 13, 2020 were retrospectively analyzed. According to the progress of the disease or not, the patients were divided into stable group and severe group. Multivariate COX proportional hazards regression analysis and dynamic changes were used to assess the high-risk factors for exacerbation of the disease. Results Finally 143 confirmed patients with COVID-19 were enrolled, the average age was 43.5(32.7, 52.4) years, 81(56.6%) cases were male, 28(19.6%) cases had at least one comorbidity (underlying disease). The most common symptom was fever (119, 83.2%), followed by dry cough (77, 53.8%). Totally, 122 patients (85.3%) had continued improvement(stable group), and 21(14.7%) deteriorated within 2 weeks of symptoms onset (severe group). Multivariate COX proportional hazards regression analysis showed that age over 60 years (HR=3.5, 95% CI 1.4-9.0), combined with underlying diseases (HR=3.9, 95% CI 1.5-10.4), LDH>250.0 U/L (HR=4.1, 95% CI 1.4-12.6), and absolute lymphocyte count less than 1.0×109/L (HR=6.8, 95% CI 2.3-20.7) were high risk factors for COVID-19 patient deterioration. Conclusions Identification of high-risk factors for deterioration of COVID-19 can assist early detection of cases with severe tendency and develop individualized and precise treatment strategy, which might alleviate the shortage of medical resources and reduce mortality.

Modelling the evolution trajectory of COVID-19 in Wuhan, China: experience and suggestions.

OBJECTIVES: In December 2019, a novel coronavirus disease (COVID-19) emerged in Wuhan city, China, which has subsequently led to a global pandemic. At the time of writing, COVID-19 in Wuhan appears to be in the final phase and under control. However, many other countries, especially the US, Italy and Spain, are still in the early phases and dealing with increasing cases every day. Therefore, this article aims to summarise and share the experience of controlling the spread of COVID-19 in Wuhan and provide effective suggestions to enable other countries to save lives. STUDY DESIGN: Data from the National Health Commission of China are used to investigate the evolution trajectory of COVID-19 in Wuhan and discuss the impacts of the intervention strategies. METHODS: A four-stage modified Susceptible-Exposed-Infectious-Removed (SEIR) model is presented. This model considers many influencing factors, including chunyun (the Spring festival), sealing off the city and constructing the Fangcang shelter hospitals. In addition, a novel method is proposed to address the abnormal data on 12-13 February as a result of changing diagnostic criteria. Four different scenarios are considered to capture different intervention measures in practice. The exposed population in Wuhan who moved out before sealing off the city have also been identified, and an analysis on where they had gone was performed using the Baidu Migration Index. RESULTS: The results demonstrate that the four-stage model was effective in forecasting the peak, size and duration of COVID-19. We found that the combined intervention measures are the only effective way to control the spread and not a single one of them can be omitted. We estimate that England will be another epicentre owing to its incorrect response at the initial stages of COVID-19. Fortunately, big data technology can help provide early warnings to new areas of the pandemic. CONCLUSIONS: The four-stage SEIR model was effective in capturing the evolution trajectory of COVID-19. Based on the model analysis, several effective suggestions are proposed to prevent and control the pandemic for countries that are still in the initial phases.